Pathobiology of Modic changes

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Refined Phenotyping of Modic Changes

Low back pain (LBP) is the world's most disabling condition. Modic changes (MC) are vertebral bone marrow changes adjacent to the endplates as noted on magnetic resonance imaging. The associations of specific MC types and patterns with prolonged, severe LBP and disability remain speculative. This study assessed the relationship of prolonged, severe LBP and back-related disability, with the pres...

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Automatic Modic Changes Classification in Spinal MRI

This paper describes a novel automatic system for Modic changes classification of vertebral endplates. Modic changes are classes of vertebral degenerations visible as intensity variations in Magnetic Resonance Images (MRI). The system operates on T1 and T2 MRI. We introduce three main novelties: (1) a vertebrae alignment scheme via precise bounding boxes obtained through corner localisation, (2...

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Effect of Modic Changes in Cervical Degenerative Disease

OBJECTIVE Modic changes are signal intensity changes in adjacent vertebral bone marrow on magnetic resonance imaging. Few studies have investigated these changes with regard to the cervical spine. In this study, we investigated the associations between cervical degenerative disease and Modic changes. METHODS We conducted a retrospective collection of radiological data in patients with neck pa...

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The relationship between Modic changes and intervertebral disc degeneration

BACKGROUND Recent reported results have added to the weight of evidence supporting association between disc degeneration and Modic changes. Endplate or Modic changes are also associated with increased body mass index. The most recent study from Teichtahl et al. titled 'Modic changes in the lumbar spine and their association with body composition, fat distribution and intervertebral disc height ...

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Association between changes in lumbar Modic changes and low back symptoms over a two-year period

BACKGROUND The association of Modic changes (MC) with low back pain (LBP) is unclear. The purpose of our study was to investigate the associations between the extent of Type 1 (M1) and Type 2 (M2) MC and low back symptoms over a two-year period. METHODS The subjects (n = 64, mean age 43.8 y; 55 [86%] women) were consecutive chronic LBP patients who had M1 or mixed M1/M2 on lumbar spine magnet...

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ژورنال

عنوان ژورنال: European Spine Journal

سال: 2016

ISSN: 0940-6719,1432-0932

DOI: 10.1007/s00586-016-4459-7